This paper models how the evolving field of pharmacogenomics (PG), which is the science of using genomic markers to predict drug response, may impact drug development times, attrition rates, costs, and the future returns to research and development (R&D). While there still remains an abundance...

This paper examines available U.S. data on academic R&D expenditures and the number of papers published and the number of citations to these papers as possible measures of `output' of this enterprise. We look at these numbers for science and engineering as a whole, for 5 selected major fields,...

We examine the impact of publicly funded biomedical research on the in-house research of the for-profit pharmaceutical industry. Qualitative analysis of the history of the discovery and development of a sample of 21 significant drugs, and a program of interviews with senior managers and...

Using detailed data on biotechnology in Japan, we find that identifiable collaborations" between particular university star scientists and firms have a large positive impact on firms'" research productivity, increasing the average firm's biotech patents by 34 percent development by 27 percent,...

Individuals involved in basic research, like other workers, respond to incentives. Funding agencies provide implicit incentives when they specify the rules by which awards are made. The following analysis is an exercise in understanding incentives at an applied level. Specific rules are examined...

Previous empirical studies that have examined the links between pharmaceutical price controls, profits, cash flows, and investment in research and development (R&D) have been largely based on retrospective statistical analyses of firm- and/or industry-level data. These studies, which have...

We explore the use of patent citations to measure the "basicness" and appropriability of inventions. We propose that the basicness of research underlying an invention can be characterized by the nature of the previous patents cited by an invention; that the basicness of research outcomes relates...

As the number of independent countries increases and their economies become more integrated, we would expect to observe more multi-country currency unions. This paper explores the pros and cons for different countries to adopt as an anchor the dollar, the euro, or the yen. Although there appear...

Although it is evident that R&D has undergone a process of internationalization, and that the less-advanced economies are becoming increasingly involved in this process, the substantial body of literature in this area has been based largely on the experiences of the developed countries. This...

This paper applies a rational action/economic sociology approach to the central organizational theory question of whether action is embedded in pre-formed institutions that are relatively cheap in terms of time and energy, or to what extent action becomes embedded in newly constructed...