Benefits of pre-operative concurrent chemo-radiotherapy among elder patients with local advanced rectal cancer
Wen-Chien Ting, Chih-Jung Yeh
The pre-operative chemo-radiotherapy (Pre-OP CCRT) in aged patients with stage III rectal cancer may be less effective. We collected data from 3365 patients (2004-2012) from Taiwan Cancer Registry. Metachronous colorectal cancer and multiple cancer patients were excluded. The patients were separated in three groups, operation first, Pre-OP CCRT first and treatment without operation. SAS 9.2 Student-t, ANOVA and Chi-Square tests were used for analysis. It was found that Group II had good survival curve than the group I (HR =0.26, p<0.0001). The group III had the worst survival benefit (HR=3.38, p<0.0001). Patients with age <75 Y/O had the same survival curve (p=0.0099). Patients age between75-80Y/O had worse survival time (HR=2.91, p<0.0001). The mortality rate increased dramatically in patients old than 85Y/O but the Pre-OP CCRT still provided survival benefit (HR=6.55, p<0.0001). Pre-operative CCRT improved survival in stage III rectal cancer. Even patients with 80~85 years old still had the benefit. In old patients without major comobility and good physical status, Pre-OP CCRT was still the best choice.
Year of publication: |
February 2018
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Authors: | Ting, Wen-Chien ; Yeh, Chih-Jung |
Published in: |
International journal of management, economics and social sciences : IJMESS. - Jersey City, NJ : [Verlag nicht ermittelbar], ISSN 2304-1366, ZDB-ID 2678845-7. - Vol. 7.2018, S1, p. 142-154
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Subject: | Pre-operative concurrent chemo-radiotherapy (Pre-op CCRT) | rectal cancer | local recurrence | survival time | Ältere Menschen | Elderly people | Krebskrankheit | Cancer |
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